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In addition, LTBPs interact with other ECM proteins- from cytokines to large multi-factorial aggregates like microfibrils and elastic fibers, affecting their genesis, structure, and performance. In the present paper, we review recent advancements in the field and relate the complex roles of LTBP in development and homeostasis. The scaffold of the vibrant extracellular space is made primarily of fibronectin, collagenous and elastic fibers, and microfibrils, which provide tissues with resilience and elasticity and also serve as docking platforms for soluble factors involved in inter-cellular communication.
The LTBPs are large secreted glycoproteins structurally related to fibrillins. LTBP1 associates with SLC, forming a tripartite complex known as the large latent complex (LLC) (Figure 2).