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LTBP4 colocalizes with both fibrillins and fibulin-5 (B. Dabovic, personal communication) and might operate as a tethering factor between the microfibrils and tropo-elastin aggregates. Studies of Ltbp4S null cells and mice showed that the absence of LTBP4 causes both impaired elastin and fibulin 5 deposition, further emphasizing the importance of LTBP4-fibulin-5 interaction in venezuelan dating girls. Genetic disorders bbw escort brisbane as a result of mutations in LTBP genes in mice and humans underline the importance of the LTBP family.
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