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It would be advisable to use the full length LTBP3-LLC for testing its binding abilities towards fibrillins. LTBP4 may also compete with its family members for binding to fibrillin-1, since its binding site lies within the same fibrillin-1 peptide as that of LTBP1 and LTBP2 (Figure 3). Elastogenesis and structural organization of elastic fibers also depend on fibulin-4 and -5. Therefore, LTBPs and fibulins may compete for interaction with fibrillin 1. Recently, a few diverse factors have been shown to bind to LTBPs.
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